Summarized Research Articles

  Curcumin alleviated CKD-induced mitochondrial oxidative damage and mitochondrial dysfunction via inhibiting GSK-3β activity in skeletal muscle This study suggested that curcumin could exert beneficial effects, including weight maintenance, improved muscle function, increased mitochondrial biogenesis, and alleviated mitochondrial dysfunction by increasing adenosine triphosphate levels. Key Ideas Muscle atrophy is characterized by the loss of muscle proteins, with relation to chronic kidney disease (CKD), disuse, aging, cancer and several other disease states Currently, oxidative stress and the subsequent mitochondrial dysfunction are distinguished widely as a vital contributing factors in the process of muscle atrophy. Oxyidative stress originated from an imbalance between oxidant and antioxidant species Recent report highlights GSK-3β as a determinant of muscle mass because of its involvement in both protein biosynthesis and myuclear turnover [18] Several evidences have suggested...

  Introduction A mechanistic study of self-renewal and differentiation provides an understanding of ESCs, which can then be applied as a therapeutic strategy for ESCs Leukemia inhibitory factor (LIF) is a key regulator in the differentiation and proliferation of both ESCs and somatic stem cells (SSCs) Nanog is a homeodomain gene that maintains and regulates the development of both cells Ferulic acid reduces the expression of IL-1β and TNF-α, as well as other known inflammatory genes in LPS activated monocyte-derived macrophages Reduced the effects of obesity, insulin resistance, hyperlipidemia, hyperglycemia Reduces rat metabolic syndrome in HFD and high-fructose diet-induced obesity Obesity is observed as the abnormal distribution and massive accumulation of fat tissues Materials and methods Mouse ESCs of E14 were cultured in Dulbecco's modified Eagle’s medium (DMEM) supplemented with 15% fetal bovine serum, 2% penicillin-streptomycin, 1% nucleoside mix, L-glutamine, 10−4 M of β-m...

  The risk of overweight or obesity in association with early exposure of antibiotics remains an important public issue for health-care of children Low-dose antibiotics (LDA) have been widely used to enhance growth rate of pigs, providing a good animal model to study the underlying mechanism. In present study, 28 female piglets, weaned at 21 d, were randomly classified into two groups, receiving either a control diet or a diet supplemented with LDA for 4 weeks. Gut microbiota is involved in the digestion of proteins, lipids and carbohydrates in small intestine, and fermenting indigestible polysaccharides into low-molecular-weight metabolites, e.g. short-chain fatty acids (SCFAs). SCFAs represent 10% of the human daily energy intake and modulate crucial biological process, such as hepatic gluconeogenesis and cholesterol biosynthesis. The sub-therapeutic use of antibiotics in animal feed promotes feed intake and rapid growth. Animals and diets Twenty-eight female piglets with body we...